Thermo Fisher Scientific FAM135A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
CTSGCLSFPS APRESPCNVK YSSKSKFDAI TKQPSSTSYN FTSSISWYES SPKPQIQAFL QAKEELKLLK LPGFMYSEVP LLA

Sequence identity with orthologs:

• Mouse: 86%
• Rat: 88%

Target Information

This gene encodes a member of the cyclin family. Cyclins regulate cell cycle transitions by binding and activating cyclin-dependent protein kinases.
FAM135A also belongs to the F-box protein family, characterized by the ~40 amino acid F-box motif.
F-box proteins form part of the ubiquitin protein ligase complex SCFs (SKP1–cullin–F-box), which function in phosphorylation-dependent ubiquitination.
These proteins are classified into:

• Fbws: containing WD-40 domains
• Fbls: containing leucine-rich repeats
• Fbxs: containing various protein–protein interaction modules or no recognizable motifs

FAM135A belongs to the Fbxs class and was among the first proteins identified with an F-box motif.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.