Thermo Fisher Scientific Importin 8 Polyclonal Antibody
Human Importin 8 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 저장용액에 포함되어 안정적입니다. 연구용으로 핵 단백질 수입 경로 분석에 활용됩니다.
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Thermo Fisher Scientific Importin 8 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Importin 8 (Product #RP-91847) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term; for long term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2642716 |
Product Specific Information
Immunogen sequence:
SNNGRGEDEE EEDDDWDEEV LEETALEGFS TPLDLDNSVD EYQFFTQALI TVQSRDAAWY QLLMAPLSED QRTALQEVYT LAEHRRTVAE AKKKIEQQGG FTFENKGVLS AFNFGTVPSN N
Highest antigen sequence identity to the following orthologs:
- Mouse: 61%
- Rat: 44%
Target Information
Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to the RAN-binding protein superfamily and shares an N-terminal sequence motif with importin-beta responsible for RAN GTP binding. It binds to the nuclear pore complex (NPC) and mediates nuclear import of ribosomal proteins with classical nuclear localization signals. Importin 8, along with RANGTP and RANBP1, inhibits GAP stimulation of the RAN GTPase, and together with transportin, assists in the nuclear import of SRP19.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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