Thermo Fisher Scientific Importin 8 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Importin 8. Recombinant protein control fragment (Product #RP-91847). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Importin 8,uniProtId:O15397-1,ncbiNodeId:9606,antigenRange:917-1037,antigenLength:1037,antigenImageFileName:PA5-54881_Importin_8_O15397-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54881_Importin_8_O15397-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642716

Product Specific Information

Immunogen sequence: SNNGRGEDEE EEDDDWDEEV LEETALEGFS TPLDLDNSVD EYQFFTQALI TVQSRDAAWY QLLMAPLSED QRTALQEVYT LAEHRRTVAE AKKKIEQQGG FTFENKGVLS AFNFGTVPSN N

Highest antigen sequence identity to the following orthologs: Mouse - 61%, Rat - 44%.

Target Information

Importin 8 is a 1037 amino acid nuclear protein with a RAN binding site. It belongs to RAN-binding protein super family and hence shares an N-terminal sequence motif with importin-beta that appears to account for RAN GTP binding. It binds to the nuclear pore complex (NPC) and is well known as a transport carrier that mediates nuclear import of ribosomal proteins with a classical nuclear localization signal. Importin 8 works by binding to the nuclear pore complex and, along with RANGTP and RANBP1, inhibits the GAP stimulation of the RAN GTPase. Along with transportin it also helps in the nuclear import of SRP19.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.