Thermo Fisher Scientific ZNF423 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human ZNF423. Recombinant protein control fragment (Product #RP-107457). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZNF423,uniProtId:Q2M1K9-1,ncbiNodeId:9606,antigenRange:347-407,antigenLength:1284,antigenImageFileName:PA5-66798_ZNF423_Q2M1K9-1_Rabbit.svg,antigenImageFileNamePDP:PA5-66798_ZNF423_Q2M1K9-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2663414

Product Specific Information

Immunogen sequence: QPDSSNHSVSP DPVLGSVASM SSATPDSSAS VERGSTPDST LKPLRGQKKM RDDGQGWTKV

Highest antigen sequence identity to the following orthologs - mouse 97%, rat 97%.

Target Information

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.