Thermo Fisher Scientific Human PPAPDC1B Synthetic Peptide
인간 PPAPDC1B 아미노 말단 부위의 14개 아미노산으로 구성된 합성 펩타이드. 항체 차단용 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 PBS 버퍼에 0.1% BSA 및 0.02% sodium azide 포함. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 14 amino acids near the amino terminus of human PPAPDC1B.
PEP-0995 can be used as a blocking peptide with polyclonal antibody PA5-20881.
Target Information
Phosphatidate phosphatase (PAP) plays an important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg²⁺.
A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg²⁺-independent and NEM-insensitive membrane-associated enzymes. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg²⁺-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity.
Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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