Thermo Fisher Scientific Human PPAPDC1B Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 14 amino acids near the amino terminus of human PPAPDC1B.
PEP-0995 can be used as a blocking peptide with polyclonal antibody PA5-20881.

Target Information

Phosphatidate phosphatase (PAP) plays an important role in lipid-signaling metabolism in eukaryotic cells. Two distinct types of PAP (PAP1 and PAP2) activity have been distinguished by their subcellular localization and differential sensitivity to N-ethylmaleimide (NEM) and Mg²⁺.

A yeast diacylglycerol pyrophosphate (DGPP) phosphatase (DPP1) and mammalian DGPP phosphatase (PAP2) have been identified as Mg²⁺-independent and NEM-insensitive membrane-associated enzymes. PPAPDC1A (also known as DPPL2) and PPAPDC1B (DPPL1) form a novel type of Mg²⁺-independent and NEM-sensitive mammalian phosphatidate phosphatase showing broad substrate specificity.

Knockdown experiments indicated that this protein is involved with multiple cell signaling pathways, including the JAK-Stat3, MAP kinase, and PKC pathways. PPAPDC1B may also potentiate the estrogen receptor pathway by down-regulating DUSP22.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.