Thermo Fisher Scientific CD28 Polyclonal Antibody
CD28 단백질을 인식하는 Goat Polyclonal 항체로, Human 시료에 반응합니다. Western blot과 IHC(P)에서 사용 가능하며, 고순도의 액상 형태로 제공됩니다. T세포 활성화 연구 및 면역학적 분석에 적합합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence SQQLQVYSKTGFNCD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933331 |
Product Specific Information
- The immunizing peptide corresponds to a part of the extracellular domain.
- Tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes.
CD28 acts as a critical T cell costimulatory receptor, providing the essential second activation signal by binding CD80 and CD86 on antigen-presenting cells.
It prevents T cells from entering an anergic state or undergoing premature apoptosis.
In murine lymphoid organs and blood, all CD4+ and CD8+ T cells express CD28. In the thymus, expression is highest on immature CD3-, CD8+, and CD4+8+ cells.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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