Thermo Fisher Scientific PPP2R2B Polyclonal Antibody
Thermo Fisher Scientific의 PPP2R2B 폴리클로날 항체는 인간, 생쥐, 랫트에 반응하며 WB, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체로 세포 성장 및 분열 조절 연구에 활용됩니다. 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PPP2R2A/PPP2R2B. Recombinant protein control fragment (Product #RP-104328). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645885 |
Product Specific Information
Immunogen sequence:
YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQQNA
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, implicated in the negative control of cell growth and division. It consists of a core enzyme composed of a catalytic subunit and a constant regulatory subunit, which associates with various regulatory subunits. The B regulatory subunit modulates substrate selectivity and catalytic activity.
This gene encodes the beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease involving cerebellar degeneration and impaired coordination of speech and body movements. Multiple alternatively spliced variants encoding different isoforms have been identified. The 5′ UTR of some variants includes a CAG trinucleotide repeat sequence (7–28 copies), which can expand to 66–78 copies in cases of SCA12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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