Thermo Fisher Scientific SFPQ Polyclonal Antibody
SFPQ 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, IP 등 다양한 응용에 적합. Human과 Mouse 반응성 확인. 고순도 항원 친화 크로마토그래피 정제, 안정적 액상 형태로 제공.
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Thermo Fisher Scientific SFPQ Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:5,000–1:20,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 230–449 of Human SFPQ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.78 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547422 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12
- Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (85%), Chimpanzee (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SFPQ (Splicing Factor Proline and Glutamine Rich), also known as PSF, encodes a nuclear factor implicated in splicing and gene expression regulation. It likely forms a heteromer with NONO and participates in DNA pairing and repair.
Recent studies identified SFPQ as a downstream target of tau, showing nuclear depletion and cytoplasmic accumulation in neurons and astrocytes of Alzheimer’s disease (AD) brains. Reduced SFPQ levels may correlate with tau pathology, suggesting its key role in neurodegenerative diseases including AD.
SFPQ protein may appear as 47 kDa, 52 kDa, or 100 kDa molecules in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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