Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI14B3), TrueMAB
인간 PDCD1 단백질을 인식하는 마우스 모노클로날 항체로, WB, ICC/IF, Flow Cytometry에 적합. 고순도 친화 크로마토그래피 정제. 액상 형태, 1 mg/mL 농도. 연구용 면역반응 억제 관련 단백질 분석에 활용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:900 |
| Flow Cytometry (Flow) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI14B3 |
| Immunogen | Full length human recombinant protein of human PDCD1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cell-mediated immune responses are initiated by T lymphocytes stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs.
PD-1 binds two ligands, PDL-1 and PDL-2, and upon binding, inhibits immune activation in the absence of “danger signals” like LPS. PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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