Thermo Fisher Scientific NMT2 Monoclonal Antibody (OTI1D7), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Proteolytic degradation maintains appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, ion channels, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway degrades most proteins in the cytosol and nucleus, while others are processed via the vacuolar pathway (endosomes, lysosomes, ER).
The 26S proteasome, an ATP-dependent, multisubunit complex (~2.5 MDa), consists of a 20S proteolytic core and 19S regulatory subunits that recognize ubiquitinated proteins and assist in unfolding and translocation.
Defects in this pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.