Thermo Fisher Scientific p53 Monoclonal Antibody (X77)

Applications

Product Specifications

Product Specific Information

A suggested positive control for this product is HCT116 cell lysate.

Target Information

The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. Upon activation, p53 induces transcription of genes such as p21waf1, regulating G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.

Phosphorylation at Ser15 is important for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 plays roles in preventing proliferation of damaged cells, cancer suppression, aging, and oxidative stress responses. It is expressed at low levels in normal cells but elevated in transformed cell lines. Mutations in the TP53 gene lead to loss of tumor suppressor activity and are common in various cancers, including Li-Fraumeni syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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