Thermo Fisher Scientific THOC5 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Bovine, Dog, Horse, Rabbit, Guinea pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, and Little brown bat.

Target Information

THOC5 is a component of the THO subcomplex within the TREX complex, which specifically associates with spliced mRNA and not with unspliced pre-mRNA. It binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner near the 5′ end of mRNA, functioning in mRNA export.
The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Recruitment to viral mRNA occurs via interaction between KSHV ORF57 protein and THOC4. UAP56 serves as a bridge between THOC4 and the THO complex. THOC5, together with THOC4, participates in NXF1-NXT1 mediated nuclear export of HSP70 mRNA and may be involved in granulocyte and adipocyte differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.