Thermo Fisher Scientific PREB Recombinant Rabbit Monoclonal Antibody (JE64-56)
PREB 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot 및 파라핀 IHC에 적합함. HEK293 세포에서 발현되며 Protein A로 정제됨. 높은 특이성과 재현성을 제공하며 연구용으로 사용 가능.
- 카탈로그번호
- MA544683
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:400
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JE64-56 |
| Immunogen | Recombinant protein within human PREB aa 81–230/417 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2931141 |
Target Information
Prolactin (PRL) expression in the pituitary is limited to specific cells. Pit-1 is a pituitary-specific transcription factor that plays an important role in PRL expression, both in mature organisms and during development. The PRL promoter contains numerous Pit-1 binding sites implicated in basal and kinase-mediated gene expression.
PREB (prolactin regulatory element binding protein) regulates PRL gene expression through the 1P site, although it lacks a discernible DNA-binding motif. PREB is encoded by a single-copy gene in both mice and humans and exhibits nuclear accumulation in pituitary cells. Evidence suggests that PREB acts as a novel transcription factor assisting PRL expression alone or in concert with Pit-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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