Thermo Fisher Scientific WWTR1 Recombinant Rabbit Monoclonal Antibody (9Y6K9)
Thermo Fisher Scientific의 WWTR1 Recombinant Rabbit Monoclonal Antibody (Clone 9Y6K9)은 Hippo 신호 경로 연구에 적합한 고특이성 항체입니다. Western blot과 ELISA에 최적화되어 있으며, 인간·마우스·랫트 반응성을 보입니다. 단백질 A로 정제된 액상 항체로 -20°C 보관이 권장됩니다.
- 카탈로그번호
- MA555341
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 9Y6K9 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–270 of human TAZ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
MNPASAPPPL PPPGQQVIHV TQDLDTDLEA LFNSVMNPKP SSWRKKILPE SFFKEPDSGS HSRQSSTDSS GGHPGPRLAG GAQHVRSHSS PASLQLGTGA GAAGSPAQQH AHLRQQSYDV TDELPLPPGW EMTFTATGQR YFLNHIEKIT TWQDPRKAMN QPLNHMNLHP AVSSTPVPQR SMAVSQPNLV MNHQHQQQMA PSTLSQQNHP TQNPPAGLMS MPNALTTQQQ QQQKLRLQRI QMERERIRMR QEELMRQEAA LCRQLPMEAE
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator acting as a downstream regulatory target in the Hippo signaling pathway. This pathway controls organ size and tumor suppression by restricting proliferation and promoting apoptosis.
STK3/MST2 and STK4/MST1, in complex with SAV1, phosphorylate and activate LATS1/2 with MOB1, which in turn phosphorylates and inactivates YAP1 and WWTR1/TAZ.
WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation, regulates SMADS nuclear accumulation, and couples them to transcriptional machinery such as the mediator complex. It also plays a role in stem-cell self-renewal, proliferation, and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: MA5-55341_WWTR1_Q9GZV5-1_Rabbit.svg, MA5-55341_WWTR1_Q9GZV5-1_Rabbit_PDP.jpeg)
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