Thermo Fisher Scientific SP110 Polyclonal Antibody
SP110 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 완충액에 보관됩니다. 인간 단백질에 반응하며, 면역 조절 및 감염 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human IPR1. Recombinant protein control fragment (Product #RP-105106). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2664825 |
Product Specific Information
Immunogen sequence:
PLPALIQEGRS TSVTNDKLTS KMNAEEDSEE MPSLLTSTVQ VASDNLIPQI RDKEDPQEMP HSPLGSMPEI RDNSPEPNDP E
Highest antigen sequence identity to the following orthologs:
- Mouse: 33%
- Rat: 37%
Target Information
Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene.
IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein functions as a gene transcription activator and may act as a nuclear hormone receptor coactivator.
Alternative splicing has been observed, producing three transcript variants encoding distinct isoforms. SP110 is the closest homolog of the IPR1 protein in humans.
The IPR1/Sp110 gene product may integrate intracellular pathogen signals with mechanisms controlling innate immunity, cell death, and pathogenesis.
IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.
Defects in Sp110 are associated with impaired resistance to M. tuberculosis infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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