Thermo Fisher Scientific HDAC8 Monoclonal Antibody (OTI1B2), TrueMAB
HDAC8 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 최적화되어 있습니다. 인간 시료에 반응하며, 고순도의 액상 형태로 제공됩니다. Affinity chromatography로 정제되었으며, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–243 of human HDAC8 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a critical component of transcriptional regulation, largely influenced by histone acetylation. Acetylation of lysine residues in histone tails increases DNA accessibility to transcription factors, while deacetylation is associated with transcriptional silencing.
Several mammalian nuclear histone acetylases have been identified, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1, and TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology with other HDACs but exhibits distinct tissue distribution. HDAC8 is localized to the nucleus and plays roles in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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