Thermo Fisher Scientific CD72 Polyclonal Antibody
Rabbit polyclonal antibody against human CD72, suitable for Western blot applications. Predicted to cross-react with mouse samples. Supplied in liquid form at 1 mg/mL concentration. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human CD72 (amino acids 186–214, UniProt ID: P21854-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691840 |
Product Specific Information
Predicted to react with Mouse samples.
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer, predominantly in B cells and other antigen-presenting cells such as dendritic cells and macrophages. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72, leading to SHP-1 dissociation and subsequent B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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