Thermo Fisher Scientific PARP12 Polyclonal Antibody
Rabbit에서 유래한 PARP12 폴리클로날 항체로, 인간 PARP12 단백질을 인식합니다. 액상 형태이며 0.3 mg/mL 농도로 제공됩니다. 단기 보관은 4°C, 장기 보관은 -20°C에서 권장됩니다. 연구용으로 DNA 손상 반응 및 세포 생물학 연구에 적합합니다.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PARP12 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664718 |
Product Specific Information
Immunogen sequence:
CKFGTSCKRSH DFSNSENLEK LEKLGMSSDL VSRLPTIYRN AHDIKNKSSA PSRVPPLFVP QGTSERKDSS GSVSPN
Highest antigen sequence identity to the following orthologs:
- Mouse: 73%
- Rat: 76%
Target Information
Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells.
Poly(ADP-ribose) polymerases (PARPs) constitute a large family of 18 proteins encoded by different genes, displaying a conserved catalytic domain. Among them, PARP-1 (113 kDa) and PARP-2 (62 kDa) are the only enzymes whose catalytic activity is immediately stimulated by DNA strand breaks.
Novel PARP family members expand the field of poly(ADP-ribosyl)ation to various cellular processes, including proliferation and cell death. Some members interact with each other, share partners and subcellular localizations, suggesting fine-tuned regulation of this post-translational modification.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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