Thermo Fisher Scientific CD30 Monoclonal Antibody (mCD30.1), PE

Applications

Flow Cytometry (Flow)

• Tested Dilution: 0.1–0.2 µg / 1×10⁶ cells

Product Specifications

Additional Formats

• Biotin (MA5-28674)
• FITC (HMCD3001)
• Request custom conjugation

Target Information

CD30 (Ki-1, TNF Receptor Superfamily Member 8) is a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Originally identified on Hodgkin’s and Reed-Sternberg cells using monoclonal antibody Ki-1, CD30 interacts with its ligand CD30L (CD153) to mediate effects such as cell proliferation, activation, differentiation, and apoptosis.
CD30 plays a crucial role in the pathophysiology of Hodgkin’s disease and other CD30⁺ lymphomas, acting as a costimulatory molecule in thymic negative selection. It is expressed on Hodgkin’s and Reed-Sternberg cells, certain non-Hodgkin’s lymphomas (including Burkitt’s), virus-infected T/B cells, and activated normal T/B cells.
In T cells, CD30 is found on subsets producing Th2-type cytokines and on CD4⁺/CD8⁺ thymocytes co-expressing CD45RO and IL4 receptor. Soluble CD30 (sCD30) serves as a marker of Th2 immune response. TRAF2 and TRAF5 interact with CD30 to activate NF-κB signaling, regulating apoptosis and limiting autoreactive CD8 effector T cell proliferation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
CD30 is expressed by mononuclear cells in Hodgkin’s lymphoma, Reed-Sternberg cells, and most Anaplastic Large Cell Lymphomas (ALCL), as well as embryonal carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지