Thermo Fisher Scientific CD25/IL2RA (Activated Lymphocyte Marker) Monoclonal Antibody (IL2RA/2395)
CD25/IL2RA 단일클론 항체로 활성화된 림프구 마커 검출에 사용. 인간 시료 반응성, IHC 및 Peptide Array에 적합. Recombinant IL2RA 단백질을 면역원으로 사용. 단백질 A/G로 정제된 액상 형태, 1 mg/mL 농도. 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 2–4 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL2RA/2395 |
| Immunogen | Recombinant fragment of human IL2RA protein (around aa 42–183) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD25 (IL2 receptor alpha chain, IL2RA) is a cytokine receptor involved in the proliferation of T and B lymphocytes. The IL2RA receptor forms a heterotrimeric complex with IL2RB and IL2RG, constituting a high-affinity IL2 receptor.
Homodimeric IL2RA chains produce low-affinity receptors, while IL2RB homodimers yield medium-affinity receptors. Expression of IL2 in mature thymocytes is monoallelic, allowing precise gene regulation.
IL2 is primarily produced by mature T cells and functions as a growth and differentiation factor, as well as a regulator of cell death. It stimulates B cell proliferation, enhances natural killer cell activity, and inhibits granulocyte macrophage colony formation.
Disruption of the IL2RA gene in mice leads to ulcerative colitis-like disease, indicating its role in immune response regulation. Mutations are associated with interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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