Thermo Fisher Scientific UFD1L Monoclonal Antibody (OTI3A12), TrueMAB
Thermo Fisher Scientific의 UFD1L 단클론 항체(OTI3A12)는 인간 UFD1L 단백질을 표적하는 고특이성 TrueMAB 제품입니다. Western blot에 최적화되어 있으며, 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3A12 |
| Immunogen | Full length human recombinant protein of human UFD1L produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Ubiquitin-mediated proteolysis requires the transfer of ubiquitin (Ub) to lysine groups on selected cellular proteins, which potentiates their degradation by the 26S proteasome. Ub-fusions are cleaved by Ub-specific processing proteases (UBps) or via the Ub-fusion degradation (UFD) pathway. The UFD1 protein was first characterized in yeast S. cerevisiae and later identified in humans as UFD1L. In vitro, UFD1 attenuates degradation of Ub-fusions with substitutions at Gly76 through selective multiubiquitination. Mutations in the UFD1 gene are linked to CATCH22 syndrome, associated with cardiac defects, cleft palate, and hypocalcemia, suggesting involvement of this pathway in developmental disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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