Thermo Fisher Scientific Syntaphilin Polyclonal Antibody
인간 Syntaphilin 단백질에 특이적인 Rabbit Polyclonal 항체로, IHC(P)에서 1:200~1:500 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% 글리세롤) 용액 형태. 단기 4°C, 장기 -20°C 보관 권장.
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- PA583964
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- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SNPH. Recombinant protein control fragment (Product #RP-99330). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2791116 |
Product Specific Information
Immunogen sequence:
FPASNTYEKL LCGMEAGVQA SCMQERAIQT DFVQYQPDLD TILEKVTQAQ VCGTDPESGD RCPELDAHPS GPRDPNSAVV V
Target Information
Syntaphilin was initially identified in a yeast two-hybrid screen using the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25.
Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis.
It also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show increased mitochondrial motility and reduced axonal mitochondrial density, correlating with enhanced short-term facilitation and impaired motor ability. Multiple isoforms are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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