Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI2H6), TrueMAB
L1CAM 단백질을 인식하는 Mouse monoclonal 항체로, Western blot, IHC, ICC, Flow Cytometry에 사용 가능. Human 시료에 반응하며, 고순도 Affinity chromatography로 정제됨. 신경세포 발달 연구용에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H6 |
| Immunogen | Full length human recombinant protein of human L1CAM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.66 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
L1CAM (also known as CD171) is an axonal glycoprotein belonging to the immunoglobulin supergene family.
Its ectodomain consists of several immunoglobulin-like domains and fibronectin type III-like repeats, connected via a single transmembrane sequence to a conserved cytoplasmic domain.
This cell adhesion molecule is critical in nervous system development, including neuronal migration and differentiation.
Mutations in the L1CAM gene cause X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus).
Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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