Thermo Fisher Scientific KITLG Monoclonal Antibody (OTI5E9), TrueMAB
인간 KITLG(SCF) 단백질을 인식하는 단클론 항체로 Western blot에 적합. 마우스 IgG1 아이소타입이며, 액상 형태로 제공. 고순도 친화 크로마토그래피 정제. -20°C에서 보관하며 반복 동결·해동은 피해야 함.
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Applications
- Western Blot (WB): 1:4,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E9 |
| Immunogen | Full length human recombinant KITLG protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting therapeutic potential in inflammatory diseases such as asthma. At least two isoforms of SCF are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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