Thermo Fisher Scientific CD56/NCAM1/NKH1 Monoclonal Antibody (NCAM1, 795)
CD56/NCAM1/NKH1 단클론 항체로 인간과 랫트 시료에서 반응. WB, IHC, ICC/IF, Flow Cytometry에 적합. 비결합형 액상 형태로 1 mg/mL 농도. 신경세포 접착 및 면역세포 마커 연구용.
- 카탈로그번호
- 4684-MSM5-P1ABX
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NCAM1, 795 |
| Immunogen | Recombinant human NCAM1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that acts as an adhesive molecule. It is expressed in the nervous system in isoforms ranging from 120–180 kDa and found on T cells and NK cells. CD56 participates in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. It is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms (retinoblastoma, medulloblastoma, astrocytomas, neuroblastoma). CD56 serves as a sensitive neuroendocrine marker for neuroendocrine and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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