Thermo Fisher Scientific Human PHLPP1 Synthetic Peptide
인간 PHLPP1의 아미노 말단 18개 아미노산 서열 기반 합성 펩타이드. 항체 PA5-34434의 블로킹 펩타이드로 사용 가능. 액상 형태, 200 µg/mL 농도, PBS(pH 7.2) + 0.1% BSA + 0.02% sodium azide 저장. 연구용으로만 사용.
- 카탈로그번호
- PEP1476
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to an 18 amino acid sequence near the amino terminus of human PHLPP1.
PEP-1476 can be used as a blocking peptide with polyclonal antibody PA5-34434.
Target Information
PHLPP1 is a member of the serine/threonine phosphatase family, which are important regulators of Akt serine-threonine kinases (AKT1, AKT2, AKT3) and conventional/novel protein kinase C (PKC) isoforms.
PHLPP1 and PHLPP2 have similar domain structures and have been shown to dephosphorylate and inactivate distinct Akt isoforms at one of the two critical phosphorylation sites required for activation (Serine473).
PHLPP2 dephosphorylates AKT1 and AKT3, whereas PHLPP1 is specific for AKT2 and AKT3.
PHLPP1 promotes apoptosis and may act as a tumor suppressor. Increased expression of PHLPP1 may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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