Thermo Fisher Scientific MUTYH Monoclonal Antibody (4D10)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Protein sequence:

KLTYQVYGLA LEGQTPVTTV PPGARWLTQE EFHTAAVSTA MKKVFRVYQG QQPGTCMGSK RSQVSSPCSR KKPRMGQQVL DNFFRSHIST DAHSLNSAAQ

Target Information

MYH (mutY homolog, E. coli) is a DNA glycosylase mismatch repair enzyme that, in conjunction with mutM (OGG1), cleaves adenine residues paired with oxidized (8-hydroxyguanines) or non-modified guanines to correct A/G and A/C mismatches.
Repair of most modified and mispaired bases in the genome is initiated by DNA glycosylases, which bind and cleave N-glycosyl bonds to initiate base excision repair.
MYH is crucial for avoiding mutations resulting from oxidative DNA damage. Multiple N-terminal splice variants of MYH exist in mammalian cells. Increasing MYH levels in A549 cells exposed to oxygen and infrared radiation improve cell survival.
Biallelic MYH germ-line mutations predispose humans to colorectal adenomas and carcinomas. MYH is abundant in neurons, where mitochondrial genomes exposed to reactive oxygen species (ROS) must maintain integrity over the mammalian lifespan.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.