Thermo Fisher Scientific TEM5 Polyclonal Antibody
다양한 종에서 반응하는 Rabbit Polyclonal TEM5 항체로, 인간 GPR124의 N말단 펩타이드를 면역원으로 사용합니다. IHC(P)에서 검증되었으며 항원 친화 크로마토그래피로 정제되었습니다. 종양 혈관신생 연구 및 TEM5 관련 연구에 적합합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bat, Dog, Horse, Human, Non-human primate, Pig, Rabbit |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 17 amino acid peptide from N-terminal extracellular domain of human GPR124 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550996 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Dog, Bat, Elephant, Panda, Horse, Rabbit, Pig, Opossum (100%).
Target Information
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for the development of anti-angiogenic therapies. These include TEM1, TEM5, TEM7, and TEM8.
TEM5, a member of the adhesion family of G protein-coupled receptors, is localized on the surface of endothelial cells and is a seven-pass transmembrane receptor, unlike TEM1, TEM7, and TEM8 which span the membrane once.
TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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