Thermo Fisher Scientific FSTL1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive control: HeLa
• Predicted reactivity: Rhesus Monkey (100%), Chimpanzee (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Follistatin-like protein 1 (FSTL1) is a widely expressed extracellular glycoprotein belonging to the osteonectin (BM-40/SPARC) family. It contains both a follistatin-like domain and an extracellular calcium-binding domain. Initially identified as a TGF-beta-inducible protein in mouse osteoblasts, FSTL1 plays roles in proliferation, differentiation, apoptosis, migration, and various biological processes including development, inflammation, angiogenesis, tumorigenesis, and immune disease pathogenesis.

FSTL1 expression is highly conserved across mammals and can be upregulated by innate immune mediators such as TLR4 agonists and IL-1β via NFκB pathways, inducing pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8). It is expressed by mesenchymal cells but absent in hematopoietic cells under normal conditions. Macrophages and monocytes can uptake FSTL1 at inflammation sites, leading to caspase-1 activation and IL-1β processing. Overexpression of FSTL1 contributes to rheumatoid arthritis and osteoarthritis, while reduced serum levels are associated with ovarian and endometrial carcinogenesis.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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