Thermo Fisher Scientific LGR5 Polyclonal Antibody
LGR5 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 인간 시료 반응성, 항원 친화 정제 방식으로 높은 특이성 제공. PBS + 10% glycerol 보존, 단기 4°C, 장기 -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 1st cytoplasmic domain of human GPR49 / LGR5. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%); Marmoset, Bovine, Bat (95%); Hamster, Elephant, Panda, Rabbit (90%); Mouse, Rat, Opossum (85%). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 10% glycerol |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2551099 |
Target Information
G protein-coupled receptor GPR49 (also known as LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from human germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, with over a thousand predicted members. They share a structural motif of seven membrane-spanning helices and exist in both active and inactive forms. Various activating ligands modulate GPCR conformation, leading to signaling via G-proteins and downstream effectors.
Studies have revealed complex regulatory mechanisms, including negative regulation (“turn-off” activity), which plays a critical role in cellular physiology and pharmacological responses. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) exemplify the therapeutic potential of this receptor family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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