Thermo Fisher Scientific FPGS Polyclonal Antibody
Thermo Fisher Scientific의 FPGS Polyclonal Antibody는 인간 FPGS 단백질을 인식하는 rabbit IgG 항체로, Western blot 등에 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관을 권장합니다.
- 카탈로그번호
- PA527914
- 판매단위
- pk
카탈로그
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Applications
Tested Application
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 222–488 of Human Folylpolyglutamate synthase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545390 |
Product Specific Information
- Recommended positive control: Folylpolyglutamate synthase transfected 293T cells
- Predicted reactivity: Bovine (81%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs.
FPGS plays a key role in folate homeostasis by:
- Preventing efflux of folate cofactors from the cell through polyglutamation
- Increasing binding of folate cofactors to enzymes involved in folate interconversion and biosynthesis
- Allowing accumulation of folates in mitochondria required for glycine synthesis
FPGS is widely expressed in human tumors and is associated with cell proliferation or lack of differentiation.
Its activity enhances the cytotoxic efficiency of folate antimetabolites used in chemotherapy.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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