Thermo Fisher Scientific CD103/ITGAE Recombinant Rabbit Monoclonal Antibody (BLR171J)
Thermo Fisher Scientific의 CD103/ITGAE Recombinant Rabbit Monoclonal Antibody (BLR171J)은 인간 CD103 인테그린 알파 E를 인식하는 고특이성 항체입니다. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합하며, HEK293F 발현 시스템에서 생산된 정제된 액상 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 6 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR171J |
| Immunogen | Peptide representing a region between residue 400 and 450 of Human Integrin alpha-E (CD103) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunocytochemistry: Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
Target Information
CD103 (ITGAE, Integrin alpha E) is expressed on mucosa-associated T lymphocytes and activated cells, as well as a subset of TGF-β1 cells. It includes a 150 kDa alpha chain and a 120 kDa beta chain. CD103 is expressed by 0.5–2% of resting lymphocytes in peripheral blood and lymphoid organs, staining a few bone marrow cells and rarely peripheral blood lymphocytes.
CD103 belongs to the integrin family, heterodimeric integral membrane proteins composed of alpha and beta chains. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, forming disulfide-linked heavy and light chains. In combination with beta 7 integrin, CD103 forms the E-cadherin binding integrin known as human mucosal lymphocyte-1 antigen.
It is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL) and may serve as an accessory molecule for IEL activation.
Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: A700-171_CD103_Integrin_alpha_E_P38570-1_Rabbit_PDP.jpeg)
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