Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), APC
돼지 CD8α 항원을 인식하는 Mouse IgG2a 단클론 항체로 APC 형광체가 결합되어 있음. Flow Cytometry에 적합하며, 고순도 정제 상태로 제공. 651/660 nm의 Excitation/Emission 특성을 가지며 4°C 암소 보관 권장.
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Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), APC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.2 µg/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 76-2-11 |
| Immunogen | Fresh dd miniature swine thymocytes |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.5, with proprietary stabilizer |
| Contains | <0.1% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745671 |
Additional Formats
- Unconjugated
- Biotin
- FITC
- PE
- PE-Cyanine5
- Custom conjugation available upon request
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin family of receptors. It plays an integral role in signal transduction, T cell differentiation, and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also found as homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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