Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), APC

Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (76-2-11), APC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 0.2 µg/10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• Biotin
• FITC
• PE
• PE-Cyanine5
• Custom conjugation available upon request

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin family of receptors. It plays an integral role in signal transduction, T cell differentiation, and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also found as homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells. Engagement of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naïve CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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