Thermo Fisher Scientific INSR Monoclonal Antibody (18-44)

Applications

Western Blot (WB)

• Tested Dilution: 1–10 µg/mL
• Publications: View 2 publications

ELISA

• Tested Dilution: —
• Publications: View 1 publication

Immunoprecipitation (IP)

• Tested Dilution: 1–10 µg/mL
• Publications: View 1 publication

Product Specifications

Product Specific Information

• MA1-10865 detects Insulin Receptor from human samples.
• Low cross-reactivity with bovine and rabbit samples.
• Suitable for Western blot and immunoprecipitation applications.
• Immunogen: human placental insulin receptor.

Target Information

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR.
In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, while IGF-1R defects may cause growth retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.