Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Angiopoietin-2 (ANG-2). Suitable for WB and IP applications. Recognizes recombinant ANG-2 protein. Supplied as liquid, unconjugated form. For research use only.
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Thermo Fisher Scientific Angiopoietin 2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 1–2 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human Angiopoietin-2 (ANG2) Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902393 |
Target Information
ANG-2 binds to the endothelial cell-specific receptor Tie-2, but unlike ANG-1, does not induce tyrosine phosphorylation. Consequently, ANG-2 modulates ANG-1 activation of Tie-2 and can act as either an agonist or antagonist of Tie-2-induced angiogenesis depending on the physiological and biochemical environment.
The signaling interactions of ANG-1, ANG-2, and Tie-2, along with ANG-3 and ANG-4, are required for embryonic and adult angiogenesis. ANG-1 and ANG-2 are associated with sprouting, tube formation, and structural integrity of newly formed blood vessels.
Mature human ANG-2 is a secreted protein containing 480 amino acids, composed of an alpha-helix-rich coiled coil N-terminal domain and a fibrinogen-like C-terminal domain. ANG-2 exists predominantly as a disulfide-linked dimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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