Thermo Fisher Scientific Caspr2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200

Immunohistochemistry (IHC)

• Tested Dilution: 1:200

Product Specifications

Product Specific Information

Product is shipped at room temperature as a lyophilized powder and should be stored at -20°C upon receipt.
Reconstitution: add 50 µL of deionized water.

Target Information

This gene encodes a member of the neurexin family functioning in the vertebrate nervous system as cell adhesion molecules and receptors.
Caspr2 protein contains epidermal growth factor repeats, laminin G domains, F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains, and a putative PDZ binding site.
It is localized at the juxtaparanodes of myelinated axons, mediating interactions between neurons and glia during nervous system development and is involved in localization of potassium channels within differentiating axons.
This gene occupies nearly 1.5% of chromosome 7 and is among the largest genes in the human genome.
It is directly regulated by FOXP2, a transcription factor related to speech and language development, and has been implicated in neurodevelopmental disorders such as Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD, and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.