Thermo Fisher Scientific Phospho-Aurora A (Thr288) Polyclonal Antibody
Aurora A (Thr288) 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품으로 연구용에 적합.
- 카탈로그번호
- 441210G
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:250 | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of human Aurora A Kinase containing threonine 288. The sequence is highly conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533590 |
Target Information
AURKA (Aurora A) is a serine/threonine kinase that regulates mitosis by association in vivo with centrosomes. Overexpression of AURKA is observed in many types of cancer. Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, related to the function of the centrosome/spindle pole region during chromosome segregation. It plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian, and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.
Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus, and spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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