ELK Biotechnology Abl1 (phospho Tyr204) rabbit pAb
Abl1 (phospho Tyr204) rabbit polyclonal antibody for WB, IHC, IF, and ELISA. Recognizes phosphorylated human Abl protein (Tyr204). Suitable for detecting cytoplasmic and nuclear localization of Abl1. High specificity and stability at -20°C for up to 1 ...
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제품명
Abl1 (phospho Tyr204) rabbit pAb
공급업체
ELK Biotechnology
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ABL1; ABL; JTK7; Tyrosine-protein kinase ABL1; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Abl around the phosphorylation site of Tyr204. AA range: 156–205 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 125 kDa (200 kDa BCR-ABL complex) |
| GeneID (Human) | 25 |
| Human Swiss-Prot No. | P00519 |
| Cellular Localization | Cytoplasm, cytoskeleton, nucleus, mitochondrion. Shuttles between nucleus and cytoplasm depending on environmental signals. Sequestered into cytoplasm via interaction with 14-3-3 proteins. Localizes to mitochondria under oxidative stress. Isoform IB: nuclear membrane, lipid-anchor. Myristoylated c-ABL protein is reported to be nuclear. |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
This gene is a proto-oncogene encoding a protein tyrosine kinase involved in cell division, adhesion, differentiation, and stress response. Its activity is negatively regulated by the SH3 domain; deletion of this region results in oncogenic activation. The protein exhibits DNA-binding activity regulated by CDC2-mediated phosphorylation, suggesting a role in the cell cycle. Abl1 is often found fused with various translocation partner genes in leukemias, notably the t(9;22) translocation forming the BCR-ABL fusion gene. Alternative splicing produces two transcript variants with different first exons spliced to common downstream exons.
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