ELK Biotechnology FR-α rabbit pAb
FR-α rabbit pAb는 인간, 마우스, 랫트에서 반응하는 폴리클로날 항체로, Western blot 및 ELISA에 적합합니다. 인간 FOLR1 유래 합성 펩타이드로 면역화되었으며, 세포막 및 세포소기관에 위치한 FR-α 단백질 검출에 사용됩니다.
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제품명
FR-α rabbit pAb
제품 개요
이 항체는 인간 FOLR1(Folate Receptor Alpha)에 특이적인 폴리클로날 항체로, WB 및 ELISA 실험에서 사용 가능합니다. 세포막 및 세포소기관에 존재하는 FR-α 단백질 검출에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | FOLR1; FOLR; Folate receptor alpha; FR-alpha; Adult folate-binding protein; FBP; Folate receptor 1; Folate receptor; adult; KB cells FBP; Ovarian tumor-associated antigen MOv18 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human FOLR1 (AA range: 41–90) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 34 kDa |
| Gene ID (Human) | 2348 |
| Human Swiss-Prot No. | P15328 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Cell membrane (Lipid-anchor, GPI-anchor); Apical/basolateral cell membrane; Secreted; Cytoplasmic vesicle; Endosome; Recycled to cell membrane after endocytosis |
Background
The protein encoded by this gene is a member of the folate receptor family. Members of this family bind folic acid and its reduced derivatives, transporting 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Multiple transcript variants encoding the same protein have been found due to alternative promoters and splicing (RefSeq, Oct 2009).
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