ELK Biotechnology ErbB-3 (phospho Tyr1289) rabbit pAb
ErbB-3 (phospho Tyr1289) rabbit pAb는 HER3 인산화 부위를 인식하는 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포막 단백질 연구 및 종양 관련 신호전달 분석에 유용합니다.
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제품명
ErbB-3 (phospho Tyr1289) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB3; HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunohistochemistry: 1/100–1/300 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER3 around the phosphorylation site of Tyr1289 (AA range: 1256–1305) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 185 kD |
| Gene ID (Human) | 2065 |
| Human Swiss-Prot No. | P21860 |
| Cellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 2: Secreted |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but lacks an active kinase domain, allowing ligand binding without direct signal transduction through phosphorylation. However, it forms heterodimers with other EGFR family members possessing kinase activity, leading to activation of pathways involved in cell proliferation and differentiation. Amplification or overexpression of this gene has been reported in various cancers including prostate, bladder, and breast tumors. Alternative splicing results in multiple isoforms, one of which lacks the transmembrane region and is secreted, modulating the activity of membrane-bound forms.
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