ELK Biotechnology Neu rabbit pAb
HER2/Neu 단백질을 인식하는 토끼 다클론 항체로, WB, IHC, IF, ELISA에 적합. 인간, 마우스, 랫트 시료에서 반응. 합성 펩타이드(AA 1206-1255) 면역원 사용. -20°C에서 1년 보관 가능.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology Neu rabbit pAb
제품명
Neu rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER2 (AA range: 1206–1255) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kD |
| Gene ID (Human) | 2064 |
| Human Swiss-Prot No | P04626 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치 (Cellular Localization)
- Isoform 1: Cell membrane; Single-pass type I membrane protein; Early endosome; Cytoplasm (perinuclear region); Nucleus.
Translocation to the nucleus requires endocytosis and importin beta-1/KPNB1 mediation. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). - Isoform 2: Cytoplasm; Nucleus
- Isoform 3: Cytoplasm; Nucleus
배경 (Background)
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases.
This protein lacks its own ligand binding domain and therefore cannot bind growth factors directly. However, it forms heterodimers with other ligand-bound EGF receptor family members, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways such as MAPK and PI3K.
Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele being Ile654/Ile655.
Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
Alternative splicing results in several additional transcript variants.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.