ELK Biotechnology Neu (phospho Tyr1112) rabbit pAb
HER2 단백질의 Tyr1112 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 세포막 및 핵에서 발현되는 HER2 단백질 연구에 유용합니다.
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제품명
Neu (phospho Tyr1112) rabbit pAb
공급업체
ELK Biotechnology
제품 설명
이 항체는 인간 HER2 단백질의 Tyr1112 인산화 부위를 기반으로 제작된 rabbit polyclonal antibody입니다. Western blot 및 ELISA 분석에 적합하며, 다양한 종(인간, 마우스, 랫트)의 HER2 단백질 검출에 사용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | ERBB2; HER2; MLN19; NEU; NGL; Receptor tyrosine-protein kinase erbB-2; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human HER2 around the phosphorylation site of Tyr1112 (AA range: 1081–1130) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 180 kDa |
| Gene ID (Human) | 2064 |
| Human Swiss-Prot No. | P04626 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Isoform 1: Cell membrane (Single-pass type I membrane protein), early endosome, cytoplasm (perinuclear region), nucleus. Nuclear translocation requires endocytosis and importin beta-1/KPNB1 mediation. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794). Isoform 2: Cytoplasm, nucleus. Isoform 3: Cytoplasm, nucleus. |
Background
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. The HER2 protein lacks a ligand-binding domain but forms heterodimers with other ligand-bound EGF receptor family members, enhancing kinase-mediated activation of downstream signaling pathways such as MAPK and PI3K. Allelic variations at amino acid positions 654 and 655 (isoform a) have been reported, with the most common allele being Ile654/Ile655. Amplification or overexpression of this gene is associated with various cancers, including breast and ovarian tumors. Alternative splicing results in multiple transcript variants.
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