ELK Biotechnology Eps15 (phospho Tyr849) rabbit pAb
Eps15 (phospho Tyr849) rabbit pAb는 EGFR 경로 관련 단백질 검출용 항체로, WB 및 ELISA에 적합합니다. 인산화 Tyr849 부위에 특이적으로 반응하며, 인간·마우스·랫에서 교차 반응성을 보입니다. 고순도 IgG 폴리클로날 항체로 장기 보관 가능.
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제품명
Eps15 (phospho Tyr849) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EPS15; AF1P; Epidermal growth factor receptor substrate 15; Protein Eps15; Protein AF-1p |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Other applications: Not yet tested |
| Immunogen | Synthesized phospho-peptide around the phosphorylation site of human Eps15 (phospho Tyr849) |
| Species Reactivity | Human; Mouse; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 100 kD |
| GeneID (Human) | 2060 |
| Human Swiss-Prot No | P42566 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
세포 내 위치
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Membrane, clathrin-coated pit.
Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.
Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.
Isoform 2: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
Colocalizes with HGS on bilayered clathrin coats on endosomes.
배경 정보
This gene encodes a protein that is part of the EGFR pathway.
The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF.
Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias.
Alternative splicing results in multiple transcript variants encoding distinct isoforms.
[provided by RefSeq, May 2009]
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