ELK Biotechnology Cortactin (phospho Tyr421) rabbit pAb

Cortactin (phospho Tyr421) rabbit pAb

제품 개요

Cortactin (CTTN)은 세포골격과 세포 부착 구조의 조절에 중요한 역할을 하는 단백질로, 본 항체는 인산화된 Tyr421 부위를 특이적으로 인식하는 rabbit polyclonal antibody입니다. 이 항체는 암세포 침윤 및 전이 연구, 세포골격 재구성 메커니즘 연구에 활용될 수 있습니다.

제품 정보

세포 내 위치

Cytoplasm, cytoskeleton, lamellipodium, ruffle, dendrite, cell membrane (peripheral membrane protein, cytoplasmic side), podosome, cell junction, focal adhesion, clathrin-coated pit, dendritic spine, and cell cortex.
Colocalizes transiently with PTK2/FAK1 at focal adhesions. Associated with membrane ruffles and lamellipodia.
In the presence of CTTNBP2NL, colocalizes with stress fibers. With CTTNBP2, localizes at the cell cortex.
Upon neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft. Colocalizes with DNM2 at the basis.

Background

Cortactin (CTTN) is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein localizes in the cytoplasm and at cell-substratum contacts. It plays dual roles in regulating adherens-type junction interactions and organizing the cytoskeleton and cell adhesion structures of epithelial and carcinoma cells. During apoptosis, cortactin is degraded in a caspase-dependent manner. Aberrant regulation contributes to tumor cell invasion and metastasis. Three splice variants encoding different isoforms have been identified (RefSeq, May 2010).