ELK Biotechnology EphA2 rabbit pAb
EphA2 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며, 세포막 및 세포 접합부에 위치한 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
EphA2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EPHA2 (AA range: 131-180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 105 kDa |
| Gene ID (Human) | 1969 |
| Human Swiss-Prot No. | P29317 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Also present in cell projection (ruffle and lamellipodium membranes) and cell junction (focal adhesion). Found at cell-cell contact regions and leading edge of migrating cells. In cancer cells, relocates from plasma membrane to cytoplasmic and perinuclear regions. |
Background
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors are involved in developmental processes, particularly in the nervous system. Receptors in this subfamily typically contain a single kinase domain and an extracellular region with a Cys-rich domain and two fibronectin type III repeats. Ephrin receptors are divided into two groups based on extracellular domain sequence similarity and ligand-binding affinities (ephrin-A or ephrin-B). Mutations in this gene are associated with certain genetically related cataract disorders. [Provided by RefSeq, May 2010]
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