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ELK Biotechnology EGFR (phospho Ser1071) rabbit pAb
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EGFR의 Ser1071 인산화 부위를 인식하는 rabbit polyclonal antibody로, Western blot과 ELISA에 적합합니다. 세포막 및 다양한 세포소기관에서 발현되는 EGFR 단백질의 인산화 상태 연구에 활용됩니다. 고순도 IgG, 1 mg/ml 농도.
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ELK Biotechnology ES5059-100UL EGFR (phospho Ser1071) rabbit pAb, 100UL pk판매 단위 pk ·
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ELK Biotechnology ES5059-50UL EGFR (phospho Ser1071) rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology EGFR (phospho Ser1071) rabbit pAb
제품명
EGFR (phospho Ser1071) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/5000 Not yet tested in other applications. |
| Immunogen | The antiserum was produced against synthesized peptide derived from human EGFR around the phosphorylation site of Ser1071. AA range: 1036–1085 |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 175 kD |
| Gene ID (Human) | 1956 |
| Human Swiss-Prot No. | P00533 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome; Endosome membrane. Nucleus. In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546, PubMed:17909029). Endocytosed upon activation by ligand (PubMed:2790960, PubMed:17182860, PubMed:27153536, PubMed:17909029). Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055). Isoform 2: Secreted. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein acts as a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, and binding induces receptor dimerization and tyrosine autophosphorylation, leading to cell proliferation. Mutations in this gene are associated with lung cancer.
[provided by RefSeq, Jun 2016]
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