ELK Biotechnology APLNR rabbit pAb

제품명

APLNR rabbit pAb

대체 명칭

APLNR; AGTRL1; APJ; Apelin receptor; Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11

적용 분야

• WB
• IHC
• IF
• ELISA

권장 희석 배수

• Western Blot: 1/500 – 1/2000
• Immunohistochemistry: 1/100 – 1/300
• Immunofluorescence: 1/200 – 1/1000
• ELISA: 1/10000
  (다른 응용은 아직 시험되지 않음)

면역원

The antiserum was produced against synthesized peptide derived from human AGTRL1.
AA range: 141–190

제품 정보

세포 내 위치

Cell membrane. After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:25639753).

배경 정보

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis, and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]