ELK Biotechnology MKP-2 rabbit pAb
인간 DUSP4 유래 펩타이드로 제작된 MKP-2 토끼 다클론 항체. WB, IHC, IF, ELISA에 사용 가능하며 핵 내 단백질 검출에 적합. ERK1/2 및 JNK 불활성화 연구에 활용. -20°C에서 1년 보관 가능.
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MKP-2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | MKP-2 rabbit pAb |
| Alternative Names | DUSP4; MKP2; VH2; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human DUSP4 (AA range: 81-130) |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kD |
| GeneID (Human) | 1846 |
| Human Swiss-Prot No | Q13115 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of this family show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
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