ELK Biotechnology Dsg1 rabbit pAb
Desmoglein-1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 ELISA에 적합. 인간 및 마우스 반응성. 세포막 및 데스모좀 위치 단백질 검출에 유용. -20°C에서 1년 보관 가능.
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제품명
Dsg1 rabbit pAb
공급업체
ELK Biotechnology
제품 개요
Desmoglein-1(DSG1)에 대한 Rabbit Polyclonal 항체로, 세포막 및 데스모좀 관련 단백질 검출에 사용됩니다. 인간 및 마우스 시료에서 반응성이 확인되었습니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Alternative Names | DSG1; CDHF4; Desmoglein-1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human DSG1 (AA range: 161–210) |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 114 kD |
| Gene ID (Human) | 1828 |
| Human Swiss-Prot No | Q02413 |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein; Cell junction, desmosome |
| Species Reactivity | Human; Mouse |
Background
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
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