ELK Biotechnology Doublecortin rabbit pAb
Doublecortin 단백질 인식용 rabbit polyclonal antibody로, 신경세포 이동 연구에 적합. WB, IHC, IF, ELISA에 사용 가능하며, 인간, 마우스, 랫트 반응성. -20°C에서 1년 보관 가능.
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제품명
Doublecortin rabbit pAb
주요 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | DCX; DBCN; LISX; Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Doublecortin (AA range: 206-255) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 44 kD |
| GeneID (Human) | 1641 |
| Human Swiss-Prot No | O43602 |
| Cellular Localization | Cytoplasm; Cell projection; Neuron projection; Localizes at neurite tips |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene encodes a member of the doublecortin family. The encoded protein is a cytoplasmic protein containing two doublecortin domains that bind microtubules. In the developing cortex, cortical neurons migrate long distances to reach their differentiation site. The protein directs neuronal migration by regulating microtubule organization and stability. It interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, essential for proper microtubule function in the developing cortex. Mutations in this gene cause abnormal neuronal migration and cortical layering defects, leading to epilepsy, mental retardation, subcortical band heterotopia (“double cortex” syndrome) in females, and lissencephaly (“smooth brain”).
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