ELK Biotechnology CYP17A1 rabbit pAb
인간 CYP17A1 단백질을 인식하는 토끼 폴리클로날 항체. WB, IHC, IF, ELISA에 사용 가능하며 다양한 희석 비율로 최적화. 스테로이드 합성 관련 효소 연구에 적합. -20°C에서 1년 보관 가능.
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제품명
CYP17A1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CYP17A1; CYP17; S17AH; Steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Cytochrome P450 17A1 (AA range: 221–270) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 50 kD |
| Gene ID (Human) | 1586 |
| Human Swiss-Prot No. | P05093 |
| Cellular Localization | Endoplasmic reticulum membrane, Microsome membrane |
| Species Reactivity | Human |
Background
Cytochrome P450 family 17 subfamily A member 1 (CYP17A1) is a member of the cytochrome P450 superfamily of enzymes. These proteins are monooxygenases catalyzing many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and exhibits both 17α-hydroxylase and 17,20-lyase activities. It is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17α-hydroxylase deficiency, 17α-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. (RefSeq, Jul 2008)
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